Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
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چکیده
منابع مشابه
Rab GEFs and GAPs.
Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain. Recent structural and cell biological studies shed new light on the mechanisms of Rab GEF and GAP action, and the cellular tr...
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Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate dissociation of the tightly bound GDP, and turned off by GAPs, which accelerate the intrinsically sluggish hydrolysis of GTP. For Ras, Rho, and Rab GTPases, this switch incorporates a membrane/cytosol alternation regulated ...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2010
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc2960